Fermentation-Derived Isosorbide Production

Introduction Isosorbide is a renewable, rigid, and thermally stable bicyclic diol derived from glucose. It plays a key role in the production of bioplastics (like polyethylene isosorbide terephthalate, PEIT), coatings, resins, and pharmaceuticals. Its fossil-based...

Biological Production of Biobased Epoxides

Introduction Epoxides are reactive three-membered cyclic ethers that serve as versatile intermediates in the production of plastics, resins, adhesives, surfactants, and pharmaceuticals. Among them, ethylene oxide, propylene oxide, and epoxidized fatty acids are most...

Enzyme Engineering for Biobased Dicarboxylic Acids

Introduction Dicarboxylic acids (DCAs) are essential platform chemicals used in polyesters, nylons, resins, adhesives, and pharmaceuticals. Common DCAs include adipic acid, succinic acid, itaconic acid, and muconic acid, which serve as the backbone for many synthetic...

Microbial Pathways for Biobased Glycolic Acid

Introduction Glycolic acid is a small organic acid (C₂H₄O₃) widely used in cosmetics, biodegradable polymers (like PGA), food processing, leather treatment, and cleaning agents. Traditionally produced via chemical synthesis from formaldehyde or monochloroacetic acid,...

Biocatalytic Conversion of Sugars to Levulinic Acid

Introduction Levulinic acid (LA) is a versatile C5 platform chemical, recognized by the US Department of Energy as one of the top bio-based building blocks. Derived from hexose sugars, it serves as a precursor for producing fuels, solvents, plasticizers, resins, and...