Enzyme-Catalyzed Synthesis of Alpha-Ketoglutaric Acid

Introduction Alpha-ketoglutaric acid (α-KG), also known as 2-oxoglutarate, is a key intermediate in the tricarboxylic acid (TCA) cycle, essential for cellular respiration, nitrogen metabolism, and biosynthesis of amino acids like glutamate. In industry, α-KG is valued...

Bio-based Production of Azelaic Acid

Introduction Azelaic acid (nonanedioic acid) is a naturally occurring C9 dicarboxylic acid valued for its applications in personal care (acne treatments, skin lightening), polymer manufacturing, lubricants, and plasticizers. Traditionally produced by ozonolysis of...

Bio-based Production of Adipic Acid from Sugars

Introduction Adipic acid (hexanedioic acid) is a key industrial dicarboxylic acid primarily used in the production of nylon-6,6, polyurethanes, plasticizers, and resins. Conventionally produced from petroleum-based cyclohexane via oxidation, this process emits...

Fermentation of Agricultural Residues to Xylitol

Introduction Xylitol is a naturally occurring five-carbon sugar alcohol (C₅H₁₂O₅) widely used as a low-calorie, non-cariogenic sweetener in food, oral care, and pharmaceutical industries. Traditionally, it is chemically synthesized by hydrogenation of xylose extracted...

Metabolic Engineering for Biobased 1,4-Butanediol

Introduction 1,4-Butanediol (BDO) is a key industrial chemical used in the synthesis of polybutylene terephthalate (PBT), polyurethanes, spandex fibers, solvents, and coatings. Traditionally derived from fossil resources such as acetylene and formaldehyde, its...