Synthesizing Acetaminophen from Lignin

Date:July 5, 2019

Country: United States

Application

• This project enables the sustainable production of acetaminophen from lignin, offering an eco-friendly alternative to fossil fuel-based manufacturing. It also supports the development of biomass-based pathways for producing valuable pharmaceuticals, plastics, and fuels.

Description

Researchers at the University of Wisconsin-Madison have developed a patented method to synthesize acetaminophen, the active ingredient in Tylenol, from lignin, a complex polymer found in plant cell walls. This renewable process offers an alternative to the fossil fuel-based production of acetaminophen and utilizes a molecule naturally present in plants like poplar. The method not only provides a sustainable source for the medication but also enhances the economics of biorefineries by creating valuable side products.

Pathway Description:

It involves converting a molecule found in lignin, specifically p-hydroxybenzoate, into acetaminophen through a series of chemical reactions. This method utilizes a biomass pretreatment process and is designed to be inexpensive and renewable, offering an alternative to traditional fossil fuel-based synthesis.