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Applications of Betulin from Acacia nilotica Bark for Cancer treatment

Date:07 June 2022

Country: India

Plant Name:

    Acacia

Residue Name:

    Bark

End Products

Biochemicals

Betulin

Medicine

Antioxidant

Application

  • Antioxidant and Anti-inflammatory: Betulin isolated from Acacia nilotica bark shows potential in combating oxidative stress and inflammation-related diseases.
  • Anticancer Activity: Betulin demonstrates promising cytotoxic effects against various cancer cell lines, suggesting its potential as a therapeutic agent in cancer treatment.

Description

This study focused on isolating and characterizing betulin (Lupan-3ß,28-diol) from the bark of Acacia nilotica using bioassay-guided fractionation. Betulin was identified through Liebermann-Burchard testing and advanced spectroscopy techniques, including NMR and MS. The compound exhibited significant biological activities, including antioxidant, anti-inflammatory, and anticancer effects, with dose-dependent inhibitory effects observed in all assays. This research highlights the potential of betulin as a bioactive compound for therapeutic applications.

 

Pathway Description:

The project involved extracting the bark of Acacia nilotica using chloroform, ethyl acetate, and acetone, followed by bioassay-guided fractionation. The ethyl acetate fraction was purified through column chromatography to isolate betulin (AN-10). The compound was identified using Liebermann-Burchard test, NMR, and MS techniques. Biological activities such as antioxidant, anti-inflammatory, and anticancer effects were evaluated using various in vitro assays.

 

Source: Know More...

Tags: Betulin ExtractionBioassay Guided FractionationHerbal Drug Discovery

End Products

Biochemicals

Betulin

Medicine

Antioxidant

Feedstock

Types of Feedstock

Forest residue

Name

Acacia nilotica Bark

Form

Isolated as pure powder

Logistics

Collected from Acacia nilotica trees grown in India Sri Lanka Sudan and Egypt

Characteristics

Exhibits significant antioxidant anti-inflammatory and anticancer activities

Pathways

Chemical

Bioassay-guided Fractionation

Stakeholders

Educational Institution

Guru Nanak Dev University (GNDU)