Adandrine: Pomegranate Peel-Based Solution for Dandruff Control

Date:31 Oct 2008

Country: France

Application

• Anti-dandruff shampoos and scalp treatments to reduce flaking and irritation.
• Scalp care products aimed at restoring skin barrier function and promoting healthy hair growth.

Description

Silab has developed an anti-dandruff ingredient, Adandrine, derived from pomegranate peel. It targets the growth of Malassezia furfur, a fungus linked to dandruff, and helps restore the skin's barrier function. The ingredient also promotes keratinocyte maturation to reduce scalp irritation. Clinical trials showed a significant reduction in desquamation after one month of use in a shampoo formulation.

Pathway Description:

The process begins by extracting Punica granatum (pomegranate) peel to obtain the active ingredient, Adandrine. This extract is combined with water, butylene glycol, and triethanolamine to create a stable formula. The ingredient inhibits Malassezia furfur growth and promotes the synthesis of involucrin, aiding in the maturation of the stratum corneum. Clinical trials involve formulating the extract into a 4% shampoo, which is then tested for its effects on desquamation and scalp irritation.